I haven't gotten to play with the bundling and minification stuff included in ASP.NET 4.5, but the stuff looks pretty cool! If you haven't heard of it yet, I highly recommend watching the following video. It's well worth the your time. I'm just learning about it now. ScottGu blogged about it back in November. Microsoft nailed this one!
To summarize it, bundling and minification basically reduced the client/server round trips and it reduces the size of the payloads. Thus, resulting in much faster page load times and better resource utilization.